Net Clinical Benefit of Edoxaban for Stroke, Mortality, and Bleeding Risk
نویسندگان
چکیده
منابع مشابه
Bleeding Risk and Mortality of Edoxaban: A Pooled Meta-Analysis of Randomized Controlled Trials
OBJECTIVE(S) Edoxaban, a factor Xa inhibitor, is a new oral anticoagulant that has been developed as an alternative to vitamin K antagonists. However, its safety remains unexplored. METHODS Medline, Embase and Web of Science were searched to March 8, 2014 for prospective, randomized controlled trials (RCTs) that assessed the safety profile of edoxaban with warfarin. Safety outcomes examined i...
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OBJECTIVE To investigate net clinical benefit (NCB) of warfarin in individuals with atrial fibrillation (AF) across stroke risk and across primary and secondary care. METHODS We conducted a linked electronic health record cohort study of 70 206 individuals with initial record of diagnosis of AF in primary (n=29 568) or secondary care (n=40 638) in England (1998-2010). We defined stroke risk a...
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There are three approaches to health economic evaluation for comparing two therapies. These are (i) cost minimization, in which one assumes or observes no difference in effectiveness, (ii) incremental cost-effectiveness, and (iii) incremental net benefit. The latter can be expressed either in units of effectiveness or costs. When analysing data from a clinical trial, expressing incremental net ...
متن کاملStroke and Bleeding Risk in Atrial Fibrillation
Non-valvular atrial fibrillation (AF) is the most common cardiac arrhythmia in the clinical setting. AF increases both the risk and severity of strokes, and is associated with substantial morbidity and mortality. Despite the clear net clinical benefit of oral anticoagulants (OACs) in patients with AF at risk for stroke, major bleeding events, especially intracranial bleeds, may be devastating. ...
متن کاملAssociation between the Risk Factors for Atherosclerosis and Diverticular Bleeding
Background and purpose: Diverticulosis is a major health problem in middle-aged and older adults. The cause of bleeding in the diverticulum is not clear, but arteriolar changes are considered as the main pathogenesis of diverticular bleeding. This study aimed at investigating the relationship between the risk factors for atherosclerosis and diverticular bleeding. Materials and methods: In this...
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ژورنال
عنوان ژورنال: JACC: Clinical Electrophysiology
سال: 2016
ISSN: 2405-500X
DOI: 10.1016/j.jacep.2015.09.015